Effect of betaine on neurological diseases

Betaine participates in the synthesis of homocysteine betaine methyltransferase in human body, catalyzes the transformation from homocysteine to methionine, which is an important bypass of methionine cycle, thus effectively preventing the accumulation of homocysteine; At the same time, the normal methionine circulation can maintain the methionine concentration in the blood, so betaine can also replace methionine to treat human liver or other diseases. Betaine can reduce the inhibition of glutamic acid decarboxylase activity by reducing the content of homocysteine in the body, which is beneficial to r_ The synthesis of aminobutyric acid strengthens the central inhibition, thereby relieving stress. Pharmacological study shows that betaine has obvious sedative effect.

Betaine in the treatment of vascular diseases

Betaine can not only replace methionine synthetase in the era of methylated disorder and cystathionine synthetase deficiency, but also act as a molecular chaperone to regulate misfolded prokaryotic and eukaryotic proteins. The adjuvant therapy of betaine can reduce homocysteine, but also increase the amount of methionine. When the methionine content exceeds 1000ttmol/L, brain edema and other adverse phenomena will occur. Therefore, the dosage of betaine must be adjusted according to the content of methionine and homocysteine in diseased plasma. Regulation of homocysteine by betaine has a certain adjuvant effect.