Creatine supplementation has been investigated for its potential benefits in metabolic health, including the management of conditions like type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Research indicates that creatine can prevent high-fat diet-induced NAFLD progression by attenuating liver fat accumulation and liver damage.

Additionally, creatine may play a role in reducing homocysteine levels, which are associated with cardiovascular risk. By supporting energy metabolism and influencing methylation processes, creatine supplementation could contribute to improved metabolic profiles. While these findings are promising, more clinical studies are needed to confirm creatine's efficacy and safety in managing metabolic disorders. Individuals considering creatine supplementation for metabolic health should consult healthcare professionals for personalized advice.